I’m always listening to Stuff You Should Know (SYSK) and The Joe Rogan Experience.
SYSK comes highly recommended for newbies. The chemistry between the hosts, Josh and Chuck, and the way they simplify even the most boring topics, is unmatched.
The Joe Rogan Experience is great too for the amazing long-form conversations. Just be prepared to sit (or walk or drive) through 3-hour long conversations that are totally worth it. I learn a lot form that show too.
I have Office Ladies on my list, as a fan of The Office. Other podcasts I occasionally listen to are The Soundtrack Show (for music geeks) and Business Wars (occasionally)